The Latest HIV News about CLRO1 Molecule that Could Reduce HIV Transmission

HIVThe latest hiv news discusses about many things which one of them is about targeting proteins in semen so the possibility to get infected by HIV is small. The investigators from the Perelman School of Medicine at the University of Pennsylvania conducted a research that refers to two approaches used to prevent HIV infection. The approaches contain a way to prevent the HIV infection by creating proteins located in semen to enhance the virus transmission. A molecule was also founded by the researchers that was named as CLRO1. This molecule works together with the semen polymers that is known as amyloid fibrils. That molecule has the ability to reduce the HIV transmission. Further researches are being conducted to fine the cure for this virus.

HIV News about How This Virus can be Transmitted

As it is known from hiv news, HIV can be transmitted through sexual interaction with someone who is HIV positive, the blood that is infected by HIV, semen or vaginal secretion, and through the semen as the virus main route. Semen is the virus main route for HIV since amyloid fibrils, kinds of proteins that create polymers is existed in it. The polymers here have a task to assign the virus to the human cells’ membranes and enhance the virus transmission up to 10,000 times. Based on Prof. James Shorter, a professor from the Perelman School of Medicine, along with colleagues suggest that HIV transmission can be reduced by reducing amyloid fibril levels in the semen. As aforementioned, both parties explained how it could be conducted in two different studies.

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The major hiv news concerning the way to reduce amyloid fibril levels in the semen is described as Hsp104, the heat shock protein that strive against amyloid fibrils so they become non-amyloid. This study was published in the journal Chemistry & Biology in 2012. The second study is about developing inactive Hsp104 frameworks which disturb the amyloid fibril assembly that lead to the non-threatening assembly protein structures. Those researches also adapted Hsp104 to match with an enzyme so they can make amyloid fibrils weak.

The CLRO1 Molecule Can Reduce HIV Transmission by 100-fold

The next study conducted by Prof. Shorter and colleagues collaborated with researchers from the Ulm University Medical Center in Germany is trying to reveal how CLRO1 molecule can work together with amyloid fibrils to enhance the HIV transmission and to thrive against the HIV virus. The molecule is described as ‘tweezer-shaped’ that has the ability to damage the amyloid fibril formation in semen and disassembles fibrils that will be made. Moreover, the CRLO1 molecule also interferes with membranes located around HIV virus particles and disarranges those particles that already have attached to amyloid fibrils.

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Based on the studies conducted by researchers, CLRO1 can reduce HIV transmission that reach over 100-fold. They also said that this molecule brings no effect on other cell membranes so it can be utilized to enhance harmless vaginal as well as anal gels that can be used to avoid getting infected by HIV. Prof. Shorter also added that CLRO1 could work better compared to other microbicides in its development because it has double action: the molecule safety and the potential it owns to be used for wide application. The experiments concerning CLRO1 have proven safe when it was applied in mice and zebrafish.